Graphene is the only form of carbon (or solid material) in which each particle is accessible for a synthetic response from two sides (because of the 2D structure). Graphene has the highest ratio/proportion of edge particles of an allotrope. Deformities inside a sheet increment its synthetic reactivity. The beginning temperature of response between the basal plane of single-layer graphene and oxygen gas is underneath 260 °C (530 K). Graphene combusts at 350 °C (620 K). Graphene is normally changed with oxygen-and nitrogen-containing functional groups and examined by infrared spectroscopy and X-ray photoelectron spectroscopy. However, determination of structures of graphene with oxygen and nitrogen functional groups requires the structures to be all around control. Contrary to the perfect 2D structure of graphene, chemical applications of graphene require either structural or chemical irregularities, as splendidly level graphene is artificially inert. As it were, the meaning of a perfect graphene is distinctive in science and material science. Graphene set on a soda-lime glass (SLG) substrate under ambient conditions showed unconstrained n-doping (1.33 × 1013 e/cm2) through surface-exchange. On p-type copper indium gallium diselenide (CIGS) semiconductor itself kept on SLG n-doping achieved 2.11 × 1013 e/cm2.